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1

An ancient genetic link between mitochondrial fatty acid synthesis and RNA processing

Kaija Autio, Alexander Kastaniotis, Helmut Pospiech, Ilkka Miinalainen, Melissa Schonauer, Carol Dieckmann, Kalervo Hiltunen

Journal:

Chemistry and Physics of Lipids

Année:

2007

Langue:

english

Fichier:

PDF, 49 KB

english, 2007

2

Protein phosphorylation in mitochondria – A study on fermentative and respiratory growth of Saccharomyces cerevisiae

Steffen Ohlmeier, J. Kalervo Hiltunen, Ulrich Bergmann

Journal:

ELECTROPHORESIS

Année:

2010

Langue:

english

Fichier:

PDF, 435 KB

english, 2010

3

Enzymatic assay for 3-hydroxyacyl-CoA and 2-trans-enoyl-CoA intermediates of β-oxidation

Pirjo M. Latipää, Ilmo E. Hassinen, J. Kalervo Hiltunen

Journal:

Analytical Biochemistry

Année:

1988

Langue:

english

Fichier:

PDF, 489 KB

english, 1988

4

The biochemistry of peroxisomal β-oxidation in the yeast Saccharomyces cerevisiae

J.Kalervo Hiltunen, Anu M. Mursula, Hanspeter Rottensteiner, Rik K. Wierenga, Alexander J. Kastaniotis, Aner Gurvitz

Journal:

FEMS Microbiology Reviews

Année:

2003

Langue:

english

Fichier:

PDF, 995 KB

english, 2003

5

Regulation of the yeast SPS19 gene encoding peroxisomal 2,4-dienoyl-CoA reductase by the transcription factors Pip2p and Oaf1p: β-oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium

Aner Gurvitz, Hanspeter Rottensteiner, J. Kalervo Hiltunen, Maximilian Binder, Ian W. Dawes, Helmut Ruis, Barbara Hamilton

Journal:

Molecular Microbiology

Année:

1997

Langue:

english

Fichier:

PDF, 445 KB

english, 1997

6

A novel mutation of the fumarase gene in a family with autosomal recessive fumarase deficiency

Anne M. Remes, Sirpa A. Filppula, Heikki Rantala, Jaakko Leisti, Aimo Ruokonen, Satyan Sharma, André H. Juffer, J. Kalervo Hiltunen

Journal:

Journal of Molecular Medicine

Année:

2004

Langue:

english

Fichier:

PDF, 486 KB

english, 2004

7

Importance of sequences adjacent to the terminal tripeptide in the import of a peroxisomalCandida tropicalisprotein in plant peroxisomes

Vanessa Bongcam, Jean MacDonald-Comber Petétot, Volker Mittendorf, Elizabeth J. Robertson, Rachel M. Leech, Yong-Mei Qin, J. Kalervo Hiltunen, Yves Poirier

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 555 KB

english, 2000

8

Structure–function relationships in MFE-2 variants found in a patient cohort—Towards understanding D-bifunctional protein deficiency as a molecular disease

Maija Malin, Henna Karvonen, Mari Ylianttila, Kristian Koski, Kalervo Hiltunen, Tuomo Glumoff

Journal:

Chemistry and Physics of Lipids

Année:

2007

Langue:

english

Fichier:

PDF, 60 KB

english, 2007

9

Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference

Anssi Pelkonen, Mikko Hiltunen, Kalervo Kiianmaa, Leonid Yavich

Journal:

Journal of Neurochemistry

Année:

2010

Langue:

english

Fichier:

PDF, 242 KB

english, 2010

10

Avoiding unscheduled transcription in shared promoters: Saccharomyces cerevisiae Sum1p represses the divergent gene pair SPS18-SPS19 through a midsporulation element (MSE)

Aner Gurvitz, Fumi Suomi, Hanspeter Rottensteiner, J. Kalervo Hiltunen, Ian W. Dawes

Journal:

FEMS Yeast Research

Année:

2009

Langue:

english

Fichier:

PDF, 197 KB

english, 2009

11

Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae

Silke Grunau, Sabrina Mindthoff, Hanspeter Rottensteiner, Raija T. Sormunen, J. Kalervo Hiltunen, Ralf Erdmann, Vasily D. Antonenkov

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 528 KB

english, 2009

12

Peroxisomal β-Oxidation and Polyunsaturated Fatty Acids

J. KALERVO HILTUNEN, SIRPA A. FILPPULA, KARI T. KOIVURANTA, KIRSI SIIVARI, YONG-MEI QIN, HELI M. HÄYRINEN

Journal:

Annals of the New York Academy of Sciences

Année:

1996

Langue:

english

Fichier:

PDF, 689 KB

english, 1996

13

Cloning and functional characterization of two cDNAs encoding NADPH-dependent 3-ketoacyl-CoA reductased from developing cotton fibers

QIN, Yong Mei, PUJOL, Francois MA, SHI, Yong Hui, FENG, Jian Xun, LIU, Yi Ming, KASTANIOTIS, Alexander J, HILTUNEN, J Kalervo, ZHU, Yu Xian

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 729 KB

english, 2005

14

Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology

Alexander J. Kastaniotis, Kaija J. Autio, Raija T. Sormunen, J. Kalervo Hiltunen

Journal:

Molecular Microbiology

Année:

2004

Langue:

english

Fichier:

PDF, 374 KB

english, 2004

15

Peroxisomal Δ3,Δ2-enoyl CoA isomerases and evolution of cytosolic paralogues in embryophytes

Simon Goepfert, Charles Vidoudez, Christian Tellgren-Roth, Syndie Delessert, J. Kalervo Hiltunen, Yves Poirier

Journal:

The Plant Journal

Année:

2008

Langue:

english

Fichier:

PDF, 999 KB

english, 2008

16

Effects of ethanol metabolites on intermediary metabolism in heart muscle

Keijo J. Peuhkurinen, Kai T. Kiviluoma, J.Kalervo Hiltunen, Timo E.S. Takala, Ilmo E. Hassinen

Journal:

Pharmacology Biochemistry and Behavior

Année:

1983

Langue:

english

Fichier:

PDF, 393 KB

english, 1983

17

Mitochondrial fatty acid synthesis and respiration

J. Kalervo Hiltunen, Kaija J. Autio, Melissa S. Schonauer, V.A. Samuli Kursu, Carol L. Dieckmann, Alexander J. Kastaniotis

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

2010

Langue:

english

Fichier:

PDF, 332 KB

english, 2010

18

Mitochondrial fatty acid synthesis and respiration

J. Kalervo Hiltunen, Kaija J. Autio, Melissa S. Schonauer, V.A. Samuli Kursu, Carol L. Dieckmann, Alexander J. Kastaniotis

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

2010

Langue:

english

Fichier:

PDF, 123 KB

english, 2010

19

Peroxisomal β-oxidation—A metabolic pathway with multiple functions

Yves Poirier, Vasily D. Antonenkov, Tuomo Glumoff, J. Kalervo Hiltunen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

2006

Langue:

english

Fichier:

PDF, 543 KB

english, 2006

20

Peroxisomal membrane permeability and solute transfer

Vasily D. Antonenkov, J. Kalervo Hiltunen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

2006

Langue:

english

Fichier:

PDF, 256 KB

english, 2006

21

The 3-hydroxyacyl-ACP dehydratase of mitochondrial fatty acid synthesis in Trypanosoma brucei

Kaija J. Autio, Jennifer L. Guler, Alexander J. Kastaniotis, Paul T. Englund, J. Kalervo Hiltunen

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 1007 KB

english, 2008

22

Structural biology of the thioester-dependent degradation and synthesis of fatty acids

Prasenjit Bhaumik, M Kristian Koski, Tuomo Glumoff, J Kalervo Hiltunen, Rik K Wierenga

Journal:

Current Opinion in Structural Biology

Année:

2005

Langue:

english

Fichier:

PDF, 565 KB

english, 2005

23

Binary Structure of the Two-Domain (3R)-Hydroxyacyl-CoA Dehydrogenase from Rat Peroxisomal Multifunctional Enzyme Type 2 at 2.38 Å Resolution

Antti M. Haapalainen, M.Kristian Koski, Yong-Mei Qin, J.Kalervo Hiltunen, Tuomo Glumoff

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 721 KB

english, 2003

24

The crystal structure of dienoyl-CoA isomerase at 1.5 å resolution reveals the importance of aspartate and glutamate sidechains for catalysis

Yorgo Modis, Sirpa A Filppula, Dmitri K Novikov, Brian Norledge, J Kalervo Hiltunen, Rik K Wierenga

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1998

25

The existence of two mitochondrial isoforms of 2,4-dienoyl-CoA reductase in the rat

Elina H. HAKKOLA, J. Kalervo HILTUNEN

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 684 KB

english, 1993

26

Characterization and Isolation of Enzymes that Hydrolyze Short-Chain acyl-CoA in Rat-Liver Mitochondria

L. Thomas Svensson, Seppo H. Kilpeläinen, J. Kalervo Hiltunen, Stefan E. H. Alexson

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 637 KB

english, 1996

27

Molecular Cloning and Characterization of the Human Mitochondrial 2,4-Dienoyl-CoA Reductase Gene (DECR)

Heli M. Helander, Kari T. Koivuranta, Nina Horelli-Kuitunen, Jorma J. Palvimo, Aarno Palotie, J.Kalervo Hiltunen

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 178 KB

english, 1997

28

The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule

Christian K Engel, Tiila R Kiema, J.Kalervo Hiltunen, Rik K Wierenga

Journal:

Journal of Molecular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 616 KB

english, 1998

29

The crystal structure of Δ3-Δ2-enoyl-CoA isomerase

Anu M Mursula, Daan M.F van Aalten, J.Kalervo Hiltunen, Rik K Wierenga

Journal:

Journal of Molecular Biology

Année:

2001

Langue:

english

Fichier:

PDF, 668 KB

english, 2001

30

Crystal structure of the liganded SCP-2-like domain of human peroxisomal multifunctional enzyme type 2 at 1.75 Å resolution

Antti M. Haapalainen, Daan M.F. van Aalten, Gitte Meriläinen, Jorma E. Jalonen, Päivi Pirilä, Rik K. Wierenga, J.Kalervo Hiltunen, Tuomo Glumoff

Journal:

Journal of Molecular Biology

Année:

2001

Langue:

english

Fichier:

PDF, 602 KB

english, 2001

31

Respiratory control in isolated perfused rat heart. Role of the equilibrium relations between the mitochondrial electron carriers and the adenylate system

Ilmo E. Hassinen, Kalervo Hiltunen

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

1975

Langue:

english

Fichier:

PDF, 644 KB

english, 1975

32

Compartmentation of citrate in relation to the regulation of glycolysis and the mitochondrial transmembrane proton electrochemical potential gradient in isolated perfused rat heart

Risto A. Kauppinen, J.Kalervo Hiltunen, Ilmo E. Hassinen

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

1982

Langue:

english

Fichier:

PDF, 476 KB

english, 1982

33

Mitochondrial membrane potential, transmembrane difference in the NAD+ redox potential and the equilibrium of the glutamate-aspartate translocase in the isolated perfused rat heart

Risto A. Kauppinen, J.Kalervo Hiltunen, Ilmo E. Hassinen

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

1983

Langue:

english

Fichier:

PDF, 702 KB

english, 1983

34

5′-nucleotidase activity and adenosine production in rat liver mitochondria

M.J. Pekka Raatikainen, Keijo J. Peuhkurinen, Kai T. Kiviluoma, J. Kalervo Hiltunen, Ilmo E. Hassinen

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

1992

Langue:

english

Fichier:

PDF, 801 KB

english, 1992

35

Regulation of fatty acid oxidation in heart muscle effects of pyruvate and dichloroacetate

Pirjo M. Latipää, J.Kalervo Hiltunen, Keijo J. Peuhkurinen, Ilmo E. Hassinen

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Année:

1983

Langue:

english

Fichier:

PDF, 1.00 MB

english, 1983

36

Subcellular distribution of phosphagens in isolated perfused rat heart

Risto A. Kauppinen, J.Kalervo Hiltunen, Ilmo E. Hassinen

Journal:

Année:

1980

Langue:

english

Fichier:

PDF, 400 KB

english, 1980

37

The glutamate dehydrogenase system and the redox state of mitochondrial free nicotinamide adenine dinucleotide in myocardium

E.Matti Nuutinen, J.Kalervo Hiltunen, Ilmo E. Hassinen

Journal:

Année:

1981

Langue:

english

Fichier:

PDF, 401 KB

english, 1981

38

β-Oxidation of unsaturated fatty acids in humans Isoforms of Δ3, Δ2-enoyl-CoA isomerase

Johanna M. Kilponen, J.Kalervo Hiltunen

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 722 KB

english, 1993

39

Subcellular distribution of myocardial 5′-nucleotidase

Kai T. Kiviluoma, J.Kalervo Hiltunen, Ilmo E. Hassinen, Keijo J. Peuhkurinen

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1990

Langue:

english

Fichier:

PDF, 716 KB

english, 1990

40

Transfer of metabolites across the peroxisomal membrane

Vasily D. Antonenkov, J. Kalervo Hiltunen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Année:

2012

Langue:

english

Fichier:

PDF, 617 KB

english, 2012

41

Site-directed mutagenesis to enable and improve crystallizability of Candida tropicalis (3R)-hydroxyacyl-CoA dehydrogenase

Mari S. Ylianttila, Yong-Mei Qin, J. Kalervo Hiltunen, Tuomo Glumoff

Journal:

Biochemical and Biophysical Research Communications

Année:

2004

Langue:

english

Fichier:

PDF, 501 KB

english, 2004

42

UK114, a YjgF/Yer057p/UK114 family protein highly conserved from bacteria to mammals, is localized in rat liver peroxisomes

Vasily D. Antonenkov, Steffen Ohlmeier, Raija T. Sormunen, J. Kalervo Hiltunen

Journal:

Biochemical and Biophysical Research Communications

Année:

2007

Langue:

english

Fichier:

PDF, 905 KB

english, 2007

43

An involvement of yeast peroxisomal channels in transmembrane transfer of glyoxylate cycle intermediates

Vasily D. Antonenkov, Sabrina Mindthoff, Silke Grunau, Ralf Erdmann, J. Kalervo Hiltunen

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2009

Langue:

english

Fichier:

PDF, 791 KB

english, 2009

44

The 1.3 Å Crystal Structure of Human Mitochondrial Δ3-Δ2-Enoyl-CoA Isomerase Shows a Novel Mode of Binding for the Fatty Acyl Group

Sanna T. Partanen, Dmitry K. Novikov, Alexander N. Popov, Anu M. Mursula, J. Kalervo Hiltunen, Rik K. Wierenga

Journal:

Journal of Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 807 KB

english, 2004

45

Crystal Structure of 2-Enoyl-CoA Hydratase 2 from Human Peroxisomal Multifunctional Enzyme Type 2

M. Kristian Koski, Antti M. Haapalainen, J. Kalervo Hiltunen, Tuomo Glumoff

Journal:

Journal of Molecular Biology

Année:

2005

Langue:

english

Fichier:

PDF, 697 KB

english, 2005

46

Structural Studies of MFE-1: the 1.9 Å Crystal Structure of the Dehydrogenase Part of Rat Peroxisomal MFE-1

Jukka P. Taskinen, Tiila R. Kiema, J. Kalervo Hiltunen, Rik K. Wierenga

Journal:

Journal of Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2006

47

Crystal Structure of Yeast Peroxisomal Multifunctional Enzyme: Structural Basis for Substrate Specificity of (3R)-hydroxyacyl-CoA Dehydrogenase Units

Mari S. Ylianttila, Niko V. Pursiainen, Antti M. Haapalainen, André H. Juffer, Yves Poirier, J. Kalervo Hiltunen, Tuomo Glumoff

Journal:

Journal of Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 736 KB

english, 2006

48

The Catalysis of the 1,1-Proton Transfer by α-Methyl-acyl-CoA Racemase Is Coupled to a Movement of the Fatty Acyl Moiety Over a Hydrophobic, Methionine-rich Surface

Prasenjit Bhaumik, Werner Schmitz, Antti Hassinen, J. Kalervo Hiltunen, Ernst Conzelmann, Rik K. Wierenga

Journal:

Journal of Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 2.81 MB

english, 2007

49

Structural Enzymological Studies of 2-Enoyl Thioester Reductase of the Human Mitochondrial FAS II Pathway: New Insights into Its Substrate Recognition Properties

Zhi-Jun Chen, Regina Pudas, Satyan Sharma, Oliver S. Smart, André H. Juffer, J. Kalervo Hiltunen, Rik K. Wierenga, Antti M. Haapalainen

Journal:

Journal of Molecular Biology

Année:

2008

Langue:

english

Fichier:

PDF, 2.53 MB

english, 2008

50

Mitochondrial fatty acid synthesis – An adopted set of enzymes making a pathway of major importance for the cellular metabolism

J. Kalervo Hiltunen, Zhijun Chen, Antti M. Haapalainen, Rik K. Wierenga, Alexander J. Kastaniotis

Journal:

Progress in Lipid Research

Année:

2010

Langue:

english

Fichier:

PDF, 824 KB

english, 2010